Pyruvate kinase M2 and its evolving role as a prognostic marker in systemic malignancies besides colorectal carcinomas
نویسندگان
چکیده
منابع مشابه
Skp2 and Its Emerging Role in the Pathogenesis of Systemic Malignancies Besides Breast Carcinomas
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Reprogrammed metabolism is a hallmark of cancer cells. Pyruvate kinase isozyme type M2 (PKM2), which is frequently up-regulated in multiple human malignancies, has been demonstrated to play a critical function in glucose metabolism, gene transcription and tumorigenesis. However, limited knowledge is known about the expression pattern and prognostic value of PKM2 in colorectal cancer (CRC). In t...
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ژورنال
عنوان ژورنال: Tumor Biology
سال: 2012
ISSN: 1010-4283,1423-0380
DOI: 10.1007/s13277-012-0528-7